Case study

Transform infected revision arthroplasty

Courtesy of Mr Ramasubramanian Dharmarajan
Cumbria, UK

Clinical particulars

A 59-year-old female patient presented with infected well fixed total knee replacement two years after primary total knee replacement surgery. This was an acute presentation with all clinical features of infection with samples testing positive for Group B Streptococcus.


First stage – radical debridement, implant removal and insertion of antibiotic loaded cement spacer and STIMULAN beads. Vancomycin was used to treat the infection.

Second stage – At 10 weeks, soft  tissues were healthy and intra-operative specimens were clear for organisms. Rotating hinge prosthesis was re-implanted.


At 1 year follow-up the patient remains infection free and is under regular follow-up.


For indications, contraindications, warnings and precautions see Instructions for Use.  The treating physician is responsible for deciding the type and quantity of antibiotic used. Concurrent use of locally administered antibiotics may affect the setting time. The mixing of antibiotics with the STIMULAN Kit / STIMULAN Rapid Cure device has not been assessed by a European medicines Competent Authority and is considered off-label usage of the medicinal product. To do so is at the professional risk of the surgeon / healthcare professional.

This brochure may include the use of STIMULAN or techniques that go beyond the current clearance / approval granted by the relevant regulatory authority. Please contact your local representative for further information.

©2017, Biocomposites, STIMULAN, Bringing Calcium to Life and Power to Transform Outcomes are trademarks/registered trademarks of Biocomposites Ltd. All rights reserved. No unauthorised copying, reproduction, distributing or republication is allowed unless prior written permission is granted by the owner, Biocomposites Ltd.

Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710

Patents pending: GB1502655.2, EP 16154210.5, US 15/040075, CN 201610089710.5, US 15/288328, GB1704688.9


Dharmarajan case study