../Biologics/Publications
Biologics - Publications
  1. Cooper JJ, Bratt JS, “New developments in hydroxyapatite ceramics”, Ceramic Technology International 1992, Ed. I Birkby, Sterling Publications, London, ISSN 0964-9735, 1992, p. 77-78.
  2. “Resorbable material shows promise for orthopaedic/dental applications”, Biomedical Materials, November 1998, Ed. P Read, International Newsletters, Oxon, UK, ISSN 0955-7177, p. 2.
  3. Harding S, Harrison P, “Immediate success with tri-calcium phosphate”, Dental Practice, April 1999, Ed. A H A Graham, A.E.Morgan Publications Ltd, Surrey UK, pp 20-21.
  4. Bratt JS, Cooper JJ, “Stimulan- A Resorbable Synthetic Substitute Filling A Space in Orthopaedic Bone Grafting” International Orthopaedic Product News (UK Edition), December 2000, Pelican Magazines Ltd, North Yorkshire, UK.
  5. McGee A, Pandya N, “Surgical Repair of Infrabony Pockets on Severely Compromised Teeth: A report on three cases in which a mixture of tri-calcium phosphate and a calcium sulphate barrier/membrane was used to good effect.”, Dental Practice, June 2000, Ed. A H A Graham, A.E.Morgan Publications Ltd, Surrey UK.
  6. Richardson JB, Kuiper JH, Cooper JJ, “Allogran-N – Making a Major Impact on Revision Arthroplasty” International Orthopaedic Product News (UK Edition), June 2001, Pelican Magazines Ltd, North Yorkshire, UK.
  7. Murray GAV, “Calcium sulphate: A Case Study with Immediate Implants” Dental Practice, November 2001, Ed. A H A Graham, A.E.Morgan Publications Ltd, Surrey UK, pp 10-12.
  8. Allum S, “Practical implantology, Part Four; Bone Augmentation and Manipulation”, Independent Dentistry, May 2002, (Now renamed Private Dentistry) Published by FMC Ltd, Hertfordshire, UK, p.42-51.
  9. Pandya NV, McGee A, Harrison P, “A New Synthetic Graft for Bone Regeneration in Periodontal Defects” Poster presentation, The American Academy of Periodontology, 88th Annual Meeting, September,2002, New Orleans, Louisiana, USA.
  10. Harrison P, “A New Material for Bone Augmantation” Presentation, Hellenic Periodontal Society, Athens, Greece, December 2002.
  11. Pandya NV, McGee A, “Treating the periodontal endodontic lesion Part 1: Non-surgical endodontics”, Dentistry, December 2002, Ed. J English, Published by FMC Ltd, Hertfordshire, UK.
  12. Pandya NV, McGee A, “Periodontal-endodontic lesion treatment Part 2: surgical therapy”, Dentistry, January 2003, Ed. J English, Published by FMC Ltd, Hertfordshire, UK.
  13. Pandya NV, McGee A, Harrison P, “Treating Perio-endo Lesions with a Synthetic Graft: Case reports” Poster presentation, EuroPerio, June, 2003, Berlin, Germany.
  14. Hadjipavlou A, “Pre-clinical and Clinical Evaluation of CaSO4 as an Extender to Autograft”, Presented at 29th HAOST (Hellenic Association of Orthopaedic Surgery and Traumatology) Spine section, September 2003, Athens, Greece.
  15. Pandya NV, McGee A, Harrison P, “Clinical Rationale of a New Synthetic Bone Augmantation Material” Poster presentation, The American Academy of Periodontology, 89th Annual Meeting, September,2003, San Fransisco, California, USA.
  16. Pandya NV, McGee A, Harrison P, “Treatment of Severe Periodontal and Periodontal-Endodontic Lesions Using a New Synthetic Augmentation Material” Poster presentation, Czech Periodontal Society Scientific Meeting, Prague, 10th – 11th October, 2003.
  17. Stallmann HP, Faber C, Slotema ET, Lyaruu DM, Bronckers AL, Amerongen AV, Wuisman PI, “Continuous-release or burst-release of the antimicrobial peptide human lactoferrin 1-11 (hLF1-11) from calcium phosphate bone substitutes.” J Antimicrob Chemother. 2003 Nov;52(5):853-5. Epub 2003 Sep 30.
  18. Yang Y, Magnay J, Cooling L, Cooper JJ, El Haj AJ, “Effects of substrate characteristics on bone cell response to the mechanical environment” Medical and Biological Engineering and Computing, January 2004, Vol. 42 (1), Publisher: Springer Berlin / Heidelberg, ISSN: 0140-0118, p.22-29.
  19. Seddon I, “Sinus grafting using a synthetic augmentation material”, Private Dentistry, October 2004, Published by FMC Ltd, Hertfordshire, UK, p.92-96.
  20. McGee A, Harrison P, “A New Synthetic Material for Bone Augmentation” Presentation, Ukrainian Implantology Society, 1st-2nd October 2004, Odessa, Ukraine.
  21. McGee A, Seddon I, “Materials for sinus graft procedures” The Dentist, November 2004, George Warman Publications (UK), p.74-76.
  22. “Biocomposites: Pioneers in Orthobiologics” Company Profile, International Orthopaedic Product News (UK Edition), November 2004, Pelican Magazines Ltd, North Yorkshire, UK.
  23. Harrison P, “Intelligent Biomaterials for Bone Growth” The Dentist, March 2005, George Warman Publications (UK), p.86-88.
  24. Heer J, “Bone Augmentation and Calcium Hydroxide Therapy”, Dentistry, March 2005, Ed. J English, Published by FMC Ltd, Hertfordshire, UK. ,pp.19-20.
  25. Gokhale S, Soliman A, Dantas JP, Richardson JB, Cook F, Kuiper JH, Jones P, “Variables affecting initial stability of impaction grafting for hip revision.” Clin Orthop Relat Res. 2005 Mar;(432):174-80.
  26. Panagopoulos P, Kanellakopoulou K, Chrysouli Z, Antoniadou A, Katsarolis I, Athanasiou K, Tsiodras S, Giamarellou H, “In vitro elution of moxifloxacin by synthetic crystallic hemihydrate form of CaSO4 (StimulanTM)”, Presented at 7th European Congress of Chemotherapy and Infection, October, 2005, Florence, Italy. Published in Journal of Chemotherapy, Vol. 17 (Suppl. 3): 67, 2005.
  27. “Knochenaufbaumaterial mit Membranfunktion” Product Feature, DI Dental Implantologie & Parodontologie No.9, 6, October 2005, Flohr Verlag, Rottweil, Germany, ISSN 1610-9988, p.508.
  28. “Synthetisches, osteokonductives Knochenaufbaumaterial mit Membranfunktion” Product Feature, Oralchirurgie Journal No.4, November 2005, © Oemus Media AG, ISSN 1617-7843, p. 43-44.
  29. Pandya NV, “Treatment of Severe Periodontal and Periodontal-Endodontic Lesions using a New Synthetic Augmentation Material”, Presentation, Czech Periodontal Society Scientific Meeting, 4th- 5th November, 2005, Karlovy Vary, Czech Republic.
  30. Bratt JS, “A Composite Treatment for Bone Repair” Orthopaedic Product News, US Edition, November/December 2005, Knowledge Enterprises Inc, Ohio, USA, p.26-27.
  31. Pacheco-Lopez I, Foy-Parrilla C, Morales-Abella O, Marrero-Rivera M, Santiago-Figueroa JM, “Intrafragmental Delivery of Analgesics in Fractures of the Distal Radius”, Podium presentation, Paper number 365, American Academy of Orthopaedic Surgeons, 73rd Annual Meeting March 2006, Chicago, Illinois, USA.
  32. Hunt JA, Cooper JJ, “The Significance of Zeta Potential in Osteogenesis” Poster presentation, Society for Biomaterials 2006 Annual Meeting, April, 2006, Pennsylvania, USA.
  33. Pandya N, “A Treatment for Severe Periodontal and Periodontal-Endodontic Lesions Without a Membrane” Poster presentation, EuroPerio, June, 2006, Madrid, Spain.
  34. Oakley J, Kuiper JH, “Factors affecting the cohesion of impaction bone graft.” J Bone Joint Surg Br. 2006 Jun;88(6):828-31.
  35. Tözüm TF, Erdal C, Saygun I, “Treatment of Periapical Dental Implant Pathology with Guided Bone Regeneration” Case Report, Turk J Med Sci. 2006; 36(3): 191-196. ©Tübitak
  36. Faber C, Bronckers ALJJ, Amerongen AVN, Wuisman PIJM, “In vitro gentamicin release from commercially available calcium-phosphate bone substitutes influence of carrier type on duration of the release profile” BMC Musculoskeletal Disorders 2006, 7:18 (26 February 2006). Copyright © 2006 Stallmann et al; licensee BioMed Central Ltd.
  37. Mavrogenis AF, Zahos KA, Benetos IS, Paliobeis C, Vlastou E, Papagelopoulos PJ, “Calcium Sulphate Delivery System with Tobramycin for the Treatment of Chronic Calcaneal Osteomyelitis” Poster presentation 38, 25th Annual Meeting of the European Bone and Joint Infection Society, 25-27th May, 2006, Budapest, Hungary.
  38. Mengel R, “Marktübersicht Augmentative Massnahmen in der zahnärztlichen Praxis” PN Parodontologie Nachrichten, May/June 2006, © Oemus Media AG.
  39. Tözüm TF, Sençimen M, Ortakoglu K, Ozdemir A, Aydin OC, Keles M, “Diagnosis and treatment of a large periapical implant lesion associated with adjacent natural tooth: a case report.”, Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Jun;101(6):e132-8. Epub 2006 May 3.
  40. Pandya NP, “Bone regeneration”, The Dentist, June 2006, George Warman Publications (UK), p.82-84.
  41. “Marktüberischt Knochenersatzmaterial.” Product listing, Implantologie Journal 4, 2006, © Oemus Media AG, p.13.
  42. Hopgood P, Kumar R, Wood PLR, “Ankle arthrodesis for failed total ankle replacement” J Bone Joint Surg Br. 2006, Vol 88-B, Issue 8, 1032-1038.
  43. Cooper JJ, “Bone Grafting- New Developments” Presentation, Welsh weekend programme, The Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK, 6th October 2006.
  44. Panagopoulos P, Kanellakopoulou K, Tsaganos T, Plachouras A, Tsiodras S, Giamarellou H, “In vitro elution of Moxifloxacin by synthetic crystallic hemihydrate form of CaSO4 (Stimulan™)” Poster presentation 184, 8th European Congress of Chemotherapy and Infection (ECC 8), 25-28th October, 2006, Budapest, Hungary.
  45. Smeets R, Stein J, Maciejewski O, Hermanns-Sachweh B, Jänicke S, Riediger D, “Nachweis der Knochenneubildung nach Sinusbodenelevation mit einem neuen ß-Tricalciumphosphat-Knochenersatzmaterial (Fortoss Vital™). Ein Fallbericht.” Poster presentation, 44. Jahrestagung der Deutschen Gesellschaft für Plastische und Wiederherstellungschirurgie e.V.; 8-11th November, 2006, Kaiser-Friedrich-Halle, Mönchengladbach.
  46. Papagelopoulos PJ, Mavrogenis AF, Tsiodras S, Vlastou C, Giamarellou H, Soucacos PN, “Calcium Sulphate Delivery System with Tobramycin for the Treatment of Chronic Calcaneal Osteomyelitis” Case Report, J Int Med Res 2006;34 (6):704-712.
  47. Zhang J, Li Y, Ping J, Rui C, “Effect of a surgical grade calcium sulfate (STIMULAN®) on the operation for jaw cysts” Journal of Shanxi Medical University 2007 Vol.38 No.2 P.167-169
  48. Merkle K, Gallardo-Lopez L, Mertens C, Arab Oghli A, Steveling HG, “The outcome of bone regeneration after augmentation with a novel Beta Tricalcium Phosphate / Calcium Sulphate graft material” Poster presentation, The Academy of Osseointegration, 22nd Annual Meeting, March 8-10 2007, San Antonio, Texas, USA.
  49. Karladani AH, “Limitations of Autograft and Allograft: New Synthetic Solutions”, Presented at the Iranian Medical Society Meeting, 17th March 2007, Los Angeles, USA.
  50. Stathakopoulos DP, Kyratzoulis IM,” Percutaneous Injectable Synthetic Calcium Sulfate for the Enhancement of Percutaneous Spinal Fusion” Poster Presentation, GRIBOI, 17th Interdisciplinary Research Conference on Biomaterials, 2-3rd April 2007, St. Catherine’s College, Oxford, UK.
  51. Gallagher JA, Dillon JP, WilsonPJM, Fraser WD, Mwaura BK, Hayton MJ, Cooper JJ, “Differential Growth of Human Osteoblastic Cells on HA and TCP with Different Surface Charge”, Presented at GRIBOI, 17th Interdisciplinary Research Conference on Biomaterials, 2-3rd April 2007, St. Catherine’s College, Oxford, UK.
  52. Lykomitros V , Konstandinidis A, Anagnostidis K, Potoupnis M, Kapetanos G, “Biomaterial injection under local anesthesia in a case of spinal compression fracture.” Presented at GRIBOI, 17th Interdisciplinary Research Conference on Biomaterials, 2-3rd April 2007, St. Catherine’s College, Oxford, UK.
  53. Cooper JJ, Hunt JA, “Enhancing the Osteogenic Potential of Bioabsorbable Implants through Control of Surface Charge”, Poster presentation number 810, Society for Biomaterials 2007 Annual Meeting, April, 2006, Chicago, Illinois, USA.
  54. McGee A, Hunt JA, “Bone Regeneration in a Bi-Lateral Sinus Lift; a Comparative Study Between Irradiated Human Cancellous Bone Versus a Synthetic Analogue”, Poster presentation, Association of Dental Implantology (ADI) Congress 3 to 5th May 2007, ICC, Birmingham, UK.
  55. Smeets R, Gerressen M, Stein J, Riediger D “Ein neues ?-Tricalciumphosphat (Fortoss Vital) als knochenersatzmaterial zur Sinusbodenaugmentation.”, Poster presentation, Deutsche Gesellschaft fur Implantologie (DGI) Annual convention, 3 to 5th May 2007, Munich, Germany.
  56. Smeets R, Stein J, Hermanns-Sachweh B, Riediger D, “Fortoss Vital™ ein neues ß-Tricalciumphosphat-Knochenersatzmaterial: Nachweis der Knochenneubildung nach Sinusbodenelevation. 57. Jahrestagung der Arbeitsgemeinschaft für Kieferchirurgie; 28. Jahrestagung des Arbeitskreises für Oralpathologie und Oralmedizin; vom 17. bis 19. Mai 2007, Wiesbaden, Germany.
  57. Stathakopoulos DP, Kyratzoulis IM,” Percutaneous Injectable Synthetic Calcium Sulfate for the Enhancement of Percutaneous Spinal Fusion” Poster Presentation #41, Hellenic Association of Orthopaedic Surgeons and Traumatology, 33rd Annual Spine meeting, 24-27th May 2007, Mykonos, Greece.
  58. Mirvakily F, Rawlinson A, Hatton PV, “Periodontal Tissue Regeneration: Modeling In Vitro Drug Delivery using Periodontal Bone Defect model.” Poster Presentation DGDP 18, Proceedings page 357, 21st European Conference on Biomaterials, 9-13th September 2007, Brighton, UK.
  59. Sivananthan S, Kuiper JH, Aulakh T, Richardson J, “Hydroxyapatite augmented impaction bone grafting in revision total hip replacement- 5 to 7 years follow up of 17 patients” Podium Presentation F017-5, 15th Triennial Congress of Asia Pacific Orthopaedic Association, 9-13th September 2007, COEX Seoul, Korea.
  60. Aulakh TS, Kuiper JH, Richardson JB, “Synthetic Bone Substitute: A Long Term Follow-up In The Context Of Survival And Functional Outcome.” Podium Presentation, Bath Biomechanics Symposium; Biomaterials in the Reconstruction of the Musculo-Skeletal System, 19th September 2007, University of Bath, UK.
  61. Podaropoulos L, Veis A, PapadImitriou S, Alexandridis C, Kalyvas D, Printza D, “Bone Regeneration Using beta-Tricalcium Phosphate in a Calcium Sulfate Matrix” Podium Presentation 0243, 42nd Annual Meeting of IADR (International Academy of Dental Research)-Continental European and Israeli Divisions, 26_29th September 2007, Thessaloniki, Greece.
  62. Bajada S, Harrison PE, Ashton BA, Cassar-Pullicino VN, Ashammakhi N, Richardson JB, “Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation” J Bone Joint Surg Br. 2007, Vol 89-B, Issue 10, 1032-1038.
  63. Fairbairn P, “The use of synthetic graft materials in the treatment of bone defects and sinus lift procedures- a clinical persective.” Podium presentation, ADI Members National Forum, 10th November 2007, Kings College University, London.
  64. Richardson JB, “Impaction grafting technique in total hip arthroplasty” Podium Presentation, 21st Annual meeting of reconstructive hip & knee surgery, Novem ber 22-24, 2007, Evgenidion Foundation, Athens, Greece.
  65. Pandya NV, “Preserving bone” The Dentist, June 2007, George Warman Publications (UK), p.60-64.
  66. Fairbairn P, “The use of Synthetic Graft Materials in the Treatment of Bone Defects and Sinus Lift Procedures - A Clinical Perspective” Presentation, ADI Scotland Study Club, February 28th 2007, Postgraduate Centre, Perth Royal Infirmary, Perth, Scotland.
  67. Aulakh TS, Kuiper JH, Richardson JB, “Synthetic Bone Substitute: A Long-Term Follow Up in the Context of Survival and Functional Outcome” Paper No. 356, 54th Annual Meeting of the Orthopaedic Research Society, March 2-5, 2008, San Francisco, USA.
  68. Mertens C, “Synthetic bone graft materials for sinus augmentation” Podium Presentation, Focus on Bone Substitutes, full day symposium (Organised by the Association of Dental Implantology, www.adi.org.uk), 28th April 2008, Manchester Conference Centre, Manchester, UK.
  69. Kuiper JH, Richardson JB, Aulakh TS, “Synthetic bone substitute: A long-term follow-up in the context of survival, revision and functional outcome.” Podium Presentation 189, 8th World Biomaterial Conference, 28th May- 1st June 2008, Amsterdam RAI, The Netherlands.
  70. Aiken S, Gallagher JA, Walsh WR, Rodger RM, “The Next Generation of Bone Graft Substitutes” Podium presentation, Spine 2008, 1 - 3 October, 2008, Uxbridge Campus of Brunel University, Uxbridge, UK.
  71. Panagopoulos P, Tsaganos T, Plachouras D, Carrer DP, Papadopoulos A, Giamarellou H, Kanellakopoulou K. “In vitro elution of moxifloxacin and fusidic acid by a synthetic crystallic semihydrate form of calcium sulphate (Stimulan).“ Int J Antimicrob Agents. 2008 Dec;32(6):485-7. Epub 2008 Sep 13.
    Abstract
    Stimulan was evaluated in vitro as a biodegradable carrier for local delivery of moxifloxacin and fusidic acid. Moxifloxacin or fusidic acid was mixed with calcium sulphate at a ratio of 95:5 to prepare five replicas per antibiotic. In vitro elution was estimated daily using a high-performance liquid chromatography (HPLC) system. Elution of moxifloxacin lasted for 31 days. Eluted concentrations reached their peak on Day 13 (mean level 745 microg/mL); the lowest eluted concentration was detected on Day 30 (mean level 367 microg/mL). Elution of fusidic acid lasted for 14 days. Eluted concentrations reached their peak on Day 6 (mean value 249.5 microg/mL); the lowest eluted concentration was detected on Day 13 (mean value 10.9 microg/mL). The presented results revealed that Stimulan may allow adequate in vitro elution of moxifloxacin and fusidic acid. The latter results support the application of this system in experimental models of osteomyelitis.
  72. Bendkowski A, “Practical and Predictable Bone Augmentation for Dental Implant Treatment” Podium Presentation, Annual Meeting of Czech Republic Implantology Club, 6th December 2008, Valtice-Schrattenberg, Czech Republic.
  73. Kanellakopoulou K, Galanopoulos I, Soranoglou V, Tsaganos T, Tziortzioti V, Maris I, Papalois A, Giamarellou H, Giamarellos-Bourboulis EJ., “Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a synthetic carrier of calcium sulphate (Stimulan((R))) releasing moxifloxacin.” Int J Antimicrob Agents. 2008 Dec 17. [Epub ahead of print]
    Abstract
    The objectives of this study were to assess the efficacy of a synthetic semihydrate form of calcium sulphate (Stimulan((R))) in experimental bone infection caused by methicillin-resistant Staphylococcus aureus (MRSA). Osteomyelitis was induced after inoculation of the test pathogen in the left tibia of 72 New Zealand rabbits assigned to the following groups: 18 control rabbits (Group A); 18 rabbits with Stimulan((R)) implanted (Group B); and 36 rabbits with moxifloxacin-impregnated Stimulan((R)) implanted (Group C). Rabbits were sacrificed at weekly intervals and cancellous bone was harvested for histopathology and for estimation of bacterial growth and concentrations of moxifloxacin. Bacterial growth from cancellous bone of Group C was significantly lower than the respective growth of Groups A and B on all days of sacrifice. The main histological finding of animals in all three groups was a moderate to intense inflammatory reaction accompanied by fibrosis. The degree of fibrosis was higher in Group C compared with both other groups. Infiltration by giant cells was also observed, which was greater in Group C on Day 42. Antibiotic levels in bone were higher for bone samples closer to the site of implantation. In conclusion, Stimulan((R)) admixed with 10% moxifloxacin was very effective in achieving complete eradication of the causative pathogen in experimental osteomyelitis caused by MRSA.Next
  74. Aulakh TS, Jayasekera N, Kuiper JH, Richardson JB. “Long-term clinical outcomes following the use of synthetic hydroxyapatite and bone graft in impaction in revision hip arthroplasty.” Biomaterials. 2009 Jan 9. [Epub ahead of print]
    Abstract
    Impaction grafting using morsellised allograft bone restores bone stock, but carries the potential for transmission of infection. Synthetic bone graft substitutes can eliminate this risk but may, however, influence outcome. In this study we tested the hypothesis that a 50/50 mix of hydroxyapatite and allograft does not affect long-term function, survival or radiological outcome. Sixty-five patients had revision hip arthroplasty using impaction grafting with either pure allograft (42 patients) or a 50/50 mixture of allograft and solid particulate hydroxyapatite. Harris hip scores were assessed pre-operatively and annual intervals thereafter. Function was analyzed using multilevel modeling, the Kaplan-Meier method used for survival analysis and graft incorporation was assessed radiologically. The hip score improved in both groups but showed a small annual decline (average 1.2/year, p<0.01). This decline was higher for females (average 3.4, p=0.025) and significantly related to pre-op scores (p<0.001). After adjusting for these, allograft patients had marginally higher scores (difference=3.1, p=0.3). The majority of revisions were for aseptic loosening. At 13 years survival in the allograft group was 84%, and 82% in the mixture group (p=0.96, log rank test). Radiologically the graft incorporation was similar in both groups (p=0.62). We conclude that long-term prosthesis survival and function following revision arthroplasty with a 50/50 mixture of allograft and hydroxyapatite are comparable to allograft alone.
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