genex®Discover a precisely balanced β-tricalcium phosphate/calcium sulfate hemihydrate compound that is the perfect partner for your trauma and non-unions – complementing the body’s natural healing processes, then vanishing without a trace.
Perfect partner for your trauma and non-unions
genex is a catalyst for bone healing. It complements the body’s natural healing processes and encourages normal bone structure to be restored at a steady rate. Over 12 months, the graft matrix is completely absorbed and replaced by bone 1,2. No foreign artifacts are left behind to impair structural integrity.
- Approved for bony voids and defects that are not intrinsic to structural stability.
- An innovative, versatile choice that supports natural healing, then vanishes without a trace.
References: 1. Yang, H.L., et al., Bone healing response to a synthetic calcium sulfate/beta-tricalcium phosphate graft material in a sheep vertebral body defect model. J Biomed Mater Res B Appl Biomater, 2012. 100B(7): p. 1911-21. 2. Data on file, Mr Nissar & Mr Gopal.
Patents granted: EP 1390086 B1, US 8632796, CN ZL02809194.9, US 8496955.
Designed to be completely absorbed and leave no trace
genex is a precisely balanced β-tricalcium phosphate/calcium sulfate hemihydrate compound with distinct design properties:
- Contains no hydroxyapatite (HA)
- Negatively charged surface chemistry
genex provides a powerful scaffold for accelerated bone restoration and helps to hinder soft tissue ingrowth:
- Fully absorbed within 12 months
- Enhances osteogenic response
- Restores strong healthy bone
Completely absorbed within 12 months1,2
|genex Implantation||6 Weeks||8 Weeks||36 Weeks|
genex contains no hydroxyapatite. HA can only be absorbed at 1–2% per year5
(Large animal model. Decalcified histology H&E stain)
Enhances the osteogenic response to accelerate bone growth – 5x normal levels6
Restores strong healthy bone within a clinically relevant timeframe2,3
|Tibial plataeu fracture||Post op||15 months|
genex restores bone to normal trabecular structure in 36 weeks1
References: 1.Yang, H.L., et al., Bone healing response to a synthetic calcium sulfate/beta-tricalcium phosphate graft material in a sheep vertebral body defect model. J Biomed Mater Res B Appl Biomater, 2012. 100B(7): p. 1911-21.2.Data on file, Mr A Nissar and Mr S Gopal.3.Data on file, Mr HK Sharma.4.Pina, S. and J.M.F. Ferreira, Bioresorbable Plates and Screws for Clinical Applications: A Review. Journal of Healthcare Engineering, 2012. 3(2).5.Cooper, J.J., J.A. Hunt, and F. Pu, Enhancing the Osteogenic Potential of Bioabsorbable Implants through Control of Surface Charge., in Society for Biomaterials 2007 Annual Meeting. 2007: Chicago, Illinois, USA.
Versatility at your fingertips
genex is versatile and easy to prepare. It comes as a paste or putty in a range of volumes. The paste sets within 15 minutes, at body temperature, and can be digitally implanted or injected in difficult-to-reach sites, or minimally invasive procedures.
|A range of surgical applications|
|PRODUCT||PASTE VOLUME||SETTING TIMES||CATALOGUE REF|
|5 cc||15 minutes approx.||900–005|
Setting paste for difficult-to-reach
|2.5 cc||15 minutes approx.||980–002|
Non-setting putty that
requires no mixing
genex offers successful long-term outcomes across a range of surgical applications, including tibial plateau fractures and long-bone non-unions
Use of genex in tibial plateau fracture
Patient presented with: Comminuted Schatzker type II fracture of right leg. X-ray examination revealed 2 large fragments and several small fragments.
Outcome: At 15 months’ follow-up the fracture had healed and knee was stable, with a range of motion of 0–130°. genex had completely absorbed.
Use of genex in proximal femur fracture
Patient presented with: Failed intramedullary nailing of an extracapsular neck of femur fracture. Patient complained of prominent metalwork and pain.
Outcome: At 12 months’ follow-up the fracture had healed with complete absorption of genex. Patient had a good range of hip motion and was able to walk and manage stairs.
Use of genex in distal tibia non-union
Patient presented with: Healed fibula with a non-union of the distal tibia and a fracture through the nail, 19 months after the initial operation.
Outcome: At 10 months’ follow-up the non-union had healed completely, patient had fully recovered and was scheduled to have the intramedullary nail removed.