STIMULAN®

STIMULAN is a pharmaceutical-grade calcium sulfate that is the perfect partner for cases with an infected site – that may help improve surgical outcomes and lower overall costs of care.

Perfect partner for cases with an infected site

STIMULAN is a truly absorbable calcium sulfate, specifically designed to complement your dead space management.1

  • Cleared for placement directly at site of infection in bone voids and defects

 

high-rates-low-rates.png

Calcium sulfate uniquely recrystallized for consistent and reliable performance in the presence of infection

hand-mat.png

STIMULAN Bullet Mat and Introducer

/media/117659/bulletmat.png

  • Simplify delivery into hard-to-reach defects.
  • Mold long bullets with a groove down one side to reduce the risk of pressurizing the defect site.
  • Bullet can be prepared in two diameters – 7mm and 9mm for varying void sizes.

 

Bullet diameter

Outside diameter

of Introducer

Minimum reamed

diameter

End-to-end lengthOrder code
7mm 9mm (black handle) 10mm 640mm  660-001
9mm 11mm (silver handle) 12mm 480mm

Reference: 1. Biocomposites Ltd, STIMULAN Instructions for Use.

For indications, contraindications, warnings and precautions see Instructions for Use.  The treating physician is responsible for deciding the type and quantity of antibiotic used.  Concurrent use of locally administered antibiotics may affect setting time.

The mixing of antibiotics with the STIMULAN Kit / STIMULAN Rapid Cure device is considered off-label usage of the medicinal product. To do so is at the professional risk of the surgeon / healthcare professional.

This page may include the use of STIMULAN or techniques that go beyond the current clearance/ approval granted by the relevant regulatory authority. Please contact your local representative for further information.

©2017, Biocomposites and STIMULAN are registered trademarks of Biocomposites Ltd. All rights reserved. No unauthorised copying, reproduction, distributing or republication is allowed unless prior written permission is granted by the owner, Biocomposites Ltd. 

Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710

Patents pending: GB1502655.2, EP 16154210.5, US 15/040075, CN 201610089710.5, US 15/288328.

Recrystallized for consistent and reliable performance

STIMULAN has a unique crystal structure and properties.

  • controlled purity
  • physiologic pH level
  • hydrophilicity

Only STIMULAN undergoes a patented recrystallization process that starts with pharmaceutical-grade reagents and results in its consistent and reliable performance.1

  • truly absorbable 
  • absorbs at an optimal rate
  • no third body damage

Hydrophilic for fast, easy mixing
No soaking required.

mixes-with-liquid.png
STIMULAN-mixes with liquid
repels-liquid.png
Competitor calcium sulfate–repels liquid

Truly absorbable and totally synthetic calcium sulfate – absorbs at an optimal rate1
Leaves no nidus for infection.

post-op.png
Post-operative
1-month.png
1 month
2-weeks.png
11 weeks
6-months.png
6 months
15-months.png
15 months

No third body damage2
Less scratching than competitor calcium sulfate and PMMA.

third-body-damage

For indications, contraindications, warnings and precautions see Instructions for Use.  The treating physician is responsible for deciding the type and quantity of antibiotic used.  Concurrent use of locally administered antibiotics may affect setting time.

The mixing of antibiotics with the STIMULAN Kit / STIMULAN Rapid Cure device is considered off-label usage of the medicinal product. To do so is at the professional risk of the surgeon / healthcare professional.

This page may include the use of STIMULAN or techniques that go beyond the current clearance/ approval granted by the relevant regulatory authority. Please contact your local representative for further information.

©2017, Biocomposites and STIMULAN are registered trademarks of Biocomposites Ltd. All rights reserved. No unauthorised copying, reproduction, distributing or republication is allowed unless prior written permission is granted by the owner, Biocomposites Ltd. 

Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710

Patents pending: GB1502655.2, EP 16154210.5, US 15/040075, CN 201610089710.5, US 15/288328.

Case-by-case flexibility

STIMULAN can be used in three bead sizes, two bullet sizes, as a paste or for injection, for optimized packing in bone voids and defects. Its hydrophilic properties and options of rapid or standard setting times make it quick and easy to prepare – helping you to adapt to each case as is merited. 

 

pellets.png

 

Flexible formats to optimize dead space management

STIMULANPASTE VOLUMEBEAD VOLUMESETTING TIMEORDER CODES
Kit (standard setting)

Fully injectable paste
with individual bead kit
5 cc 10 cc

Approx.

8 minutes

600—005
10 cc 20 cc 600—010
         
Rapid Cure 

Rapid setting paste
with individual bead kit
5 cc 12.5 cc

Approx.

4 minutes

620—005
10 cc 25 cc 620—010
20 cc 50 cc 620—020

 

 

STIMULAN Bullet Mat and Introducer

/media/117659/bulletmat.png

  • Simplify delivery into hard-to-reach defects.
  • Mold long bullets with a groove down one side to reduce the risk of pressurizing the defect site.
  • Bullet can be prepared in two diameters – 7mm and 9mm for varying void sizes.

 

Bullet diameter

Outside diameter

of Introducer

Minimum reamed

diameter

End-to-end lengthOrder code
7mm 9mm (black handle) 10mm 640mm  660-001
9mm 11mm (silver handle) 12mm 480mm

Outcomes

STIMULAN can be used in cases with an infected site to fill a bone void or defect created by a cyst, tumour, traumatic injury or osteomyelitis.

 

beads-US.pngOsteomyelitis caused by MRSA with STIMULAN beads

Patient presented with: drainage, failure of fixation and non-union 6 months after the initial ORIF calcaneus.

Outcome: Successful revision avoiding amputation and with complete absorption of STIMULAN beads at 4 months. 

Click to read full case study

 

paste-US.pngOsteomyelitis caused by Group B Streptococcus and MRSA with STIMULAN paste

Patient presented with: drainage issues, 1 year after pilon fracture repair and then 2 weeks after hardware removal.

Outcome: 6 months after treatment the patient was fully weight-bearing and without restrictions on activity—with complete absorption of STIMULAN.

Click to read full case study

 

Non-unionInfected non-union of radius and ulna

Patient presented with:infected non-union of radius and ulna with loosening of fixator, sequestrum on radiograph and wrist drop.

Outcome: complete absorption of STIMULAN within 3 months. The patient subsequently underwent reconstructive surgery and has bony union and full healing at 1 year. 

Click to read full case study

For indications, contraindications, warnings and precautions see Instructions for Use.  The treating physician is responsible for deciding the type and quantity of antibiotic used.  Concurrent use of locally administered antibiotics may affect setting time.

The mixing of antibiotics with the STIMULAN Kit / STIMULAN Rapid Cure device is considered off-label usage of the medicinal product. To do so is at the professional risk of the surgeon / healthcare professional.

This page may include the use of STIMULAN or techniques that go beyond the current clearance/ approval granted by the relevant regulatory authority. Please contact your local representative for further information.

©2017, Biocomposites and STIMULAN are registered trademarks of Biocomposites Ltd. All rights reserved. No unauthorised copying, reproduction, distributing or republication is allowed unless prior written permission is granted by the owner, Biocomposites Ltd. 

Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710

Patents pending: GB1502655.2, EP 16154210.5, US 15/040075, CN 201610089710.5, US 15/288328.

Dr Wassef case study

Infected hip revision with STIMULAN beads

Dr Webb case study

Bilateral high energy femoral fractures with STIMULAN beads

Technique Guide

See the STIMULAN Bullet Mat and Introducer in action

Testimonials

Hear what surgeons have to say about STIMULAN

Testimonials

Hear what surgeons have to say about STIMULAN

Testimonials

Hear what surgeons have to say about STIMULAN

How to prepare

STIMULAN Rapid Cure

Case studies

Read case studies for musculoskeletal infections

Case studies

Read case studies for trauma

Resources

  • STIMULAN brochure
  • FAQs

Find out more