Biocomposites Inc - geneX Putty

Preloaded Injectable bone graft with ZPC™

geneX® putty is a unique synthetic bone graft material, which possesses a consistent controlled negative surface charge (ZPC™). This initiates reproducible cell activity, driving endochondral ossification as the putty is fully resorbed and replaced by bone.

geneX® putty has been designed with an optimized composition of β-Tri Calcium Phosphate and an ultra pure Calcium Sulfate component, produced by a patented manufacturing process.

geneX® is the only bone graft material to show bone growth in the clinically relevant ’Boden’ Model, without the addition of BMPs, Autograft, marrow or growth factors.

KEY ADVANTAGES
• Negative surface charge for rapid bone formation
• Fully resorbable and replaced by bone
• Superior handling capabilities and conforms to the surgical site
• Resists migration at operative site
• Fully synthetic – eliminating the risk of disease transmission

ZPC™ Zeta Potential Control
Biocomposites has developed a unique process, ZPC™ making geneX® the only bone graft material with a controlled, reproducible negative surface charge. This process controls the graft surface properties, initiating reproducible cell activity and accelerating bone formation.1,2

Key proteins are harnessed at the graft surface, directing bone cell adhesion and proliferation for rapid osteogenesis and bone formation.

Engineered to Drive Bone Healing though three key stages


	Negative Surface charge harnesses key proteins which enhances bone cell activity and attachment.

Surface of positively charged calcium phosphate - limited cell attachment

Surface of negatively charged geneX® -
prolific cell attachment and proliferation

Positive surface charge, In-Vitro osteoblast culture,
3 days, (Toluidine Blue stain)

ZPC™ Negative Surface Charge, In-vitro osteoblast culture, 3 days, (Toluidine Blue stain)


	Sulfate phase, as it resorbs, stimulates the formation of the cartilage intermediate phase – Endochondral Ossification.

In-vivo, 4 weeks post implantation. (H&E stain, Magnification x10)


	Negative surface charge facilitates the transition from cartilage to new bone. geneX naturally resorbed through bone remodeling process. Calcium ions aid mineralization of new bone.

Residual geneX® putty is fully incorporated into new bone formation, to be naturally resorbed through remodeling processes.

In-vivo, 8 weeks post implantation. NB - New Bone,
GP - geneX® putty (H&E stain, Magnification x10)

REFERENCES
1. Ohgaki M, et al. "Manipulation of cell proliferation by electrically polarized hydroxyapatite.", Key Engineering Materials (2002), Vols 218-220, pp 249-252
2. Teng N C, et al. "A new approach to enhancement of bone formation by electrically polarized hydroxyapatite." , J Dent. Res (2001), Oct, Vol 80, No 10, pp 1925-1929.

ORDER CODES
2.5cc 5cc 10cc	920-002 920-005 920-010