Biocomposites | Antibiotic Calcium Devices For Osteomyelitis

Truly absorbable calcium sulfate antibiotic carrier approved for use in bone and soft tissue

Preformed, antibiotic loaded hip spacer to maintain space and aid treatment of infection

Synicem™ hip spacer

An innovative, versatile synthetic bone graft that supports natural healing and vanishes without a trace.

Osteoconductive calcium phosphate composite with improved strength retention and bone-bonding potential.

Biosteon®

Highly consistent, polycrystalline and porous calcium phosphate bone substitute for use in trauma and spine.

Allogran-R®

First synthetic calcium composite arthroscopic device in sports injuries to receive CE mark and FDA clearance.

Bilok®

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Your specialty

Access case studies, clinical and pre-clinical papers for musculoskeletal infection, trauma and spine to see how we are innovating across a wide range of clinical applications to help surgeons and their patients.

Musculoskeletal infections

Musculoskeletal infections, including infected non-unions, osteomyelitis and periprosthetic joint infections, are one of the biggest healthcare challenges of the 21st century.

As the rapid growth of antibiotic-resistant strains and biofilms continues to outpace the development of new antibiotics and antibiotic strategies, care delivery is becoming increasingly challenging and complicated.

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Transform Infected Femur

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Transform infected foot ulcer

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Transform diabetic foot ulcer

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Trauma

Bone and joint trauma, such as fractures and dislocations, are common and vary in severity from single fractures to multiple, life-threatening musculoskeletal injuries.

The most clinically challenging of these for the surgeon, and those that have the most socioeconomic burden, are open fractures. These often involve damage to the surrounding soft tissue, resulting in complications such as tissue and deep bone infection or long-term non-union.

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Effect of a synthetic osteoconductive bone graft substitute with zeta potential control (geneX®ds) in the treatment of intertrochanteric fracture: A single center experience of 115 consecutive proximal femoral nail antirotations

Shin, W. C., et al. Journal of Orthopaedic Science 2019, 24(5):842-849.

Effectiveness of the management of bony articular collapse with bony defects in tibial plateau fractures with the use of genex: An absorbable calcium composite synthetic bone graft

Lowery, K., et al. Journal of Limb Lengthening & Reconstruction 2018, 4(1): 20-25.

Arthroscopically assisted use of injectable bone graft substitutes for management of scaphoid nonunions

Chu, P. J. and J. T. Shih. Arthroscopy 2011, 27(1): 31-37.

Spine

The popularity of spine surgery differs around the world. The number of procedures performed in the USA is double the number performed in Western Europe, Canada and Australia combined, and five times the number in the UK.

In the USA, the number of spinal fusion procedures increased by 64% between 2002 and 2014, from approximately 268,000 to 414,000. The average cost per procedure has increased from $15,868 to $28,954 over the same period and was more than $12 billion in total in 2014.

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Bone healing response to a synthetic calcium sulfate/beta-tricalcium phosphate graft material in a sheep vertebral body defect model

Yang, H. L., et al. J Biomed Mater Res B Appl Biomater 2012, 100(7): 1911-1921.

The spine clinics – Postoperative spinal infections – Clinical scenarios

Upendra, B., et al. (2018). Indian Spine Journal 1(1): 32-45.

Preliminary clinical experience with polyetheretherketone cages filled with synthetic crystallic semihydrate form of calcium sulfate for anterior cervical discectomy and fusion

Chang, M.-Y., et al. (2013). Formosan Journal of Surgery 46(4): 109-115.