Uniquely engineered for the precision and control you demand every time

Bullet Mat and Introducer

Streamlined, flexible design that simplifies delivery of STIMULAN into hard-to-reach defects.

Perfect partner for your infection management strategy

STIMULAN is a truly absorbable calcium sulfate precision engineered to complement your dead space and infection management strategies – helping you to improve surgical outcomes and lower overall costs of care.

  • Approved for placement directly at the site of infection¹

Consistency is hard earned and uniquely achieved

STIMULAN is uniquely engineered through our DRy26™ recrystallization method.2 Each and every synthesis undergoes a 26 step process that starts with pharmaceutical grade precursors and takes over 6 weeks to reach maturity.

Properties that drive performance

The unique crystal configuration and construction of STIMULAN brings its own set of qualities to fully support your infected cases.

  • Physological pH
  • Controlled purity
  • No hydroxyapatite, insoluble impurities or PMMA debris
  • Hydrophilic

See the STIMULAN difference in your cases

  • Truly absorbable1, 3-9
  • Optimal absorption profile1, 3-9
  • Reliable setting time9
  • Does not cause third body damage10-12
  • Does not prevent use in articulating surfaces10-12
  • Does not act as a nidus for infection1, 3-9
  • Low levels of drainage13-19
Truly absorbable and totally synthetic calcium sulfate – absorbs at an optimal rate

Leaves no nidus for infection.

1 month
11 weeks
6 months
Low levels of drainage

No third body damage to articulating surfaces

Less scratching than competitor calcium sulfate

STIMULAN does not damage total knee replacements when trapped between the articulating surfaces of the implant

Microscope images (x6.5) of a cobalt chrome plate following damage simulation(360,000 cycles) with third body particles trapped between it and an articulating UHMWPE pin

Competitor calcium sulfate

Unrivalled evidence and expertise bring confidence

With our industry-leading knowledge, dedication and experience, you can be sure that the high level of consistency you demand in your cases will be met.

Case-by-case flexibility

Every part of STIMULAN has been designed to provide simplicity, intra-operative flexibility and optimum results. A variety of formats are available, all convenient and fast to set

STIMULAN® products
STIMULAN® Bullet Mat and Introducer

Innovative design that simplifies delivery into hard-to-reach defects.

  • Bullets have a groove down one side to reduce the risk of pressurizing the defect site
  • Bullets can be prepared in two diameters – 7mm and 9mm
STIMULAN® Rapid Cure

Rapid setting paste with individual bead kit.

  • Beads can be prepared in three sizes;
    3, 4.8 and 6mm
  • Available in 5cc, 10cc and 20cc packs (bead volume 12cc, 25cc and 50cc)
  • Rapid setting in approx. 4 minutes

Standard setting, fully injectable paste with individual bead kit.

  • Beads can be prepared in three sizes;
    3, 4.8 and 6mm
  • Available in 5cc and 10cc packs (bead volume 10cc and 20cc)
  • Standard setting in approx. 8 minutes
STIMULAN - power to transform outcomes
STIMULAN - power to transform outcomes
STIMULAN Bullet Mat and Introducer technique guide
How to prepare STIMULAN Rapid Cure
Hear what surgeons have to say about STIMULAN
Dr Hohman case study - tibial osteomyelitis
Dr Wassef case study - infected hip revision
Dr Webb case study - bilateral high energy femoral fractures
Hear what surgeons have to say about STIMULAN
Case studies

References and regulatory statements

1. Biocomposites Ltd, STIMULAN Instructions for Use. 2. Cooper, J.J., Method of producing surgical grade calcium sulphate; Patent. 1999. 3. Somasundaram, K., et al., Proximal humeral fractures: the role of calcium sulphate augmentation and extended deltoid splitting approach in internal fixation using locking plates. Injury, 2013. 44(4): p. 481-7. 4. Lei, D., et al., Treatment of Distal Radius Bone Defects with Injectable Calcium Sulphate Cement., in Bone Grafting, A. Zorzi, Editor. 2012, InTech. p. 125-134. 5. Lei, D., L. Jing, and S. Yang-yong, Calcium sulfate versus calcium phosphate in treating traumatic fractures. JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH., 2008. 12. 6. Lei, D., Z. Ma, and X. Jing, Treatment of bone defect with injectable calcium sulfate powder in distal fractures of radius. Chinese Journal of Bone Tumor and Bone Disease, 2007. 7. Aiken, S.S., J.J. Cooper, and S. Zhou, Osseointegration of a calcium sulphate bone substitute in a large animal model, in The 5th International Congress of Chinese Orthopaedic Association. 2010: Chengdu, China. 8. Lazarou, S.A., G.B. Contodimos, and I.D. Gkegkes, Correction of alveolar cleft with calcium-based bone substitutes. J Craniofac Surg, 2011. 22(3): p. 854-7. 9. Biocomposites, Data on file. 10. Cowie, R.M., et al., Influence of third-body particles originating from bone void fillers on the wear of ultra-high-molecular-weight polyethylene. Proc Inst Mech Eng H, 2016. 230(8): p. 775-83. 11. Cowie, R.M., et al., The Influence of Third Body Damage by a Calcium Sulfate Bone Void Filler on the Wear of Total Knee Replacements., in Orthopaedic Research Society Annual Meeting. 2016: Orlando, FL. p. 103. 12. Lewicki, K., et al., The Effect of Absorbable Calcium Sulfate on Wear Rates in Ultra-high-Molecular-weight Polyethylene: Potential Implications for Its Use in Treating Arthroplasty Infections. J Am Acad Orthop Surg, 2017. 13. McPherson, E.J., Dissolvable Antibiotic Beads in Treatment of Periprosthetic Joint Infection. The Use of Synthetic Pure Calcium Sulfate (Stimulan®) Impregnated with Vancomycin & Tobramycin, in 2nd Annual Oxford Bone Infection Conference (OBIC). 2012: Oxford, UK. 14. McPherson, E.J., M.V. Dipane, and S.M. Sherif, Dissolvable Antibiotic Beads in Treatment of Periprosthetic Joint Infection and Revision Arthroplasty. The Use of Synthetic Pure Calcium Sulfate (Stimulan®)Impregnated with Vancomycin & Tobramycin. Reconstructive Review, 2013. 3(1): p. 32-43. 15. Gauland, C., The use of antibiotic impregnated, implanted synthetic calcium sulphate tablets in the treatment of soft tissue, vancomycin resistant, enterococcus infections, in The Symposium on Advanced Wound Care and Wound Healing Society Annual Meeting. 2011: Gaylord Texan Hotel & Convention Center, Dallas, Texas. 16. Borrelli, J., Jr., W.D. Prickett, and W.M. Ricci, Treatment of nonunions and osseous defects with bone graft and calcium sulfate. Clin Orthop Relat Res, 2003(411): p. 245-54. 17. Helgeson, M.D., et al., Antibiotic-impregnated calcium sulfate use in combat-related open fractures. Orthopedics, 2009. 32(5): p. 323. 18. McKee, M.D., et al., The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Trauma, 2002. 16(9): p. 622-7. 19. Noor, S., et al., The use of Osteoset-T in the treatment of chronic osteomyelitis of the tibia following exogenous trauma: A review of 22 patients at a regional trauma centre. Bone & Joint Journal Orthopaedic Proceedings Supplement, 2013. 95-B(SUPP 23): p. 4.

For indications, contraindications, warnings and precautions see Instructions for Use.  The treating physician is responsible for deciding the type and quantity of antibiotic used.  Concurrent use of locally administered antibiotics may affect setting time. The mixing of antibiotics with the STIMULAN Kit / STIMULAN Rapid Cure device has not been assessed by a European medicines Competent Authority and is considered off-label usage of the medicinal product. To do so is at the professional risk of the surgeon / healthcare professional. This brochure may include the use of STIMULAN or techniques that go beyond the current clearance / approval granted by the relevant regulatory authority. Please contact your local representative for further information.

©2019, Biocomposites, STIMULAN, Bringing Calcium to Life, Power to Transform Outcomes and DRy26 are trademarks/registered trademarks of Biocomposites Ltd. All rights reserved. No unauthorised copying, reproduction, distributing or republication is allowed unless prior written permission is granted by the owner, Biocomposites Ltd.

Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710, EP 3058899 B1.

Patents pending: GB1502655.2, US 15/040075, CN 201610089710.5, US 15/288328, GB1704688.9, EP 18275044.8, US 15/933936, CN 108619579A