A Single Center Retrospective Evaluation of a Surgical Strategy to Combat Persistent Soft Tissue Wounds Utilizing Absorbable Antibiotic Beads

Gorvetzian, J.W., R.P. Kunkel, and C.P. Demas. Adv Wound Care (New Rochelle), 2019. 8(2): p. 49-57.
Products: STIMULAN®
In this retrospective review, the use of STIMULAN in chronic soft tissue wounds was assessed in 60 patients with contaminated wounds with the potential presence of biofilm. Surgical interventions in the 90 days before surgical intervention using STIMULAN were compared to the incidence of reoperation and surgical site infections in the following 90 days. STIMULAN was used as a carrier material for a range of antibiotics including vancomycin, gentamicin, tobramycin, rifampin, and daptomycin. In all cases, STIMULAN was combined with two or more antimicrobials. In the 90 days preceding intervention with STIMULAN, patients had required 129 reoperations which included 100 reoperations (78%) for wound infection. Within the 90 days of STIMULAN assisted surgery, 19 reoperations were required with 4 cases (4.8%) for wound infection. The study concluded that significantly decreased infectious and all-cause reoperations for chronic and infected wounds was associated with the use of STIMULAN in surgery. The abstract can be read, and the full paper can be obtained here.
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