Effect of a synthetic osteoconductive bone graft substitute with zeta potential control (geneX®ds) in the treatment of intertrochanteric fracture: A single center experience of 115 consecutive proximal femoral nail antirotations

Shin, W. C., et al. Journal of Orthopaedic Science 2019, 24(5):842-849.
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The purpose of this retrospective study was to identify the clinical effect of the application of geneX®ds in elderly patients with low-energy hip fractures treated with proximal femoral nail antirotation (PFNA). The study compared the preoperative details and surgical outcomes, including radiologic and clinical outcomes of 233 patients.
  • The study showed that sliding distance at 1, 3, and 12 months follow-up in the geneX®ds unstable fracture group was significantly shorter than that in the no geneX®ds group when anatomical or extramedullary reduction was achieved postoperatively.
  • The study data showed that any complications, including sterile inflammation, wound dehiscence, the infection, delayed wound healing and local pain related to the use of geneX®ds were not identified.
  • The author states that “Our findings suggest that the use of a synthetic osteoconductive bone graft substitute with zeta potential control may have a positive effect on the controlled sliding of the helical blade and the fracture healing of intertrochanteric fractures”.
  • Confirmed bone union was achieved in 97.4% (227) of patients
The abstract can be read, and the full paper can be obtained at here
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