Case study

Transform chronic draining sinus with Serratia in left ankle

Courtesy of Dr. Christopher P Demas
Professor and Chief, Division of Plastic Surgery, Albuquerque, New Mexico

Clinical particulars

69 year-old male presented with a complex history of his left ankle. The patient was initially treated for a left closed pilon fracture of the distal tibia with open reduction internal fixation. Over the following 13 years, the patient underwent ankle fusion, medial plantar island flap reconstruction due to wound breakdown, and several treatments for wound dehiscence. After an occurrence of wound dehiscence about the medial aspect of the ankle, the patient was hospitalised, an I&D was performed and cultures tested positive for MRSA. The patient underwent weekly wound care visits with daily packing changes at home.

In total, the patient endured fifteen surgeries prior to presenting with chronic draining sinus. He was hospitalised and cultures tested positive for Serratia.


Debridement of scarred skin, deep tissue and bone within the chronic osteomyelitis cavity was carried out to remove all non-viable tissue. STIMULAN paste was injected to fill the resulting dead space. The cavity was covered with a reverse sural flap and I.V. antibiotics were administered to treat the infection.


The patient underwent debridement satisfactorily with partial absorption of STIMULAN paste at 3 months. The patient was fully healed and free from infection 14 months after treatment, and remains infection free 2 years after treatment


For indications, contraindications, warnings and precautions see Instructions for Use.  The treating physician is responsible for deciding the type and quantity of antibiotic used.  Concurrent use of locally administered antibiotics may affect setting time.

The mixing of antibiotics with the STIMULAN Kit / STIMULAN Rapid Cure device is considered off-label usage of the medicinal product. To do so is at the professional risk of the surgeon / healthcare professional.

This page may include the use of STIMULAN or techniques that go beyond the current clearance/ approval granted by the relevant regulatory authority. Please contact your local representative for further information.

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Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710, EP 3058899 B1

Patents pending: GB1502655.2, US 15/040075, CN 201610089710.5, US 15/288328, GB1704688.9, EP 18275044.8, US 15/933936